The Virtual Brain (TVB) is a scientific simulation platform that models both human brain structure and function. It is a tool that redefines our limits of understanding the human brain while enabling us to generate, manipulate and visualize a biologically realistic brain in an indeterminate number of states.
TVB is based on the assumption that structural information provides certain constraints on the type of network dynamics that may emerge. While these constraints limit arbitrary brain dynamics, structural connectivity provides the foundation on top of which a range of brain network configurations can emerge. When brain structure is changed, as in maturation, aging, or from damage or disease, then the brain’s repertoire inevitably changes.
TVB allows the systematic investigation of the brain’s repertoire as a function of structure. It moves away from the investigation of isolated regional responses and considers the function of each region in terms of the interplay among brain regions. This allows us to (1) re-classify lesions in terms of the network of nodes (regions) and connections (axons, white matter tracts) that have been damaged and to (2) investigate the mechanisms that preserve function by understanding how regional damage affects the function of other parts of the network. In this context, brain repair (recovery of function) depends on the restoration and rebalancing of activity in the remaining nodes in the network.
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